Non-Ligand-Induced Dimerization is Sufficient to Initiate the Signalling and Endocytosis of EGF Receptor

Non-Ligand-Induced Dimerization is Sufficient to Initiate the Signalling and Endocytosis of EGF Receptor

The binding of epidermal growth factor (EGF) to EGF receptor (EGFR) stimulates cell mitogenesis and survival through various signalling cascades. EGF also stimulates rapid EGFR endocytosis and its eventual degradation in lysosomes. The immediate events induced by ligand binding include receptor dime...

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Bibliographic Details
Main Authors: George Kourouniotis, Yi Wang, Steven Pennock, Xinmei Chen, Zhixiang Wang
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:International Journal of Molecular Sciences
Subjects:
EGF receptors
endocytosis
signal transduction
leucine zipper
dimerization
Online Access:http://www.mdpi.com/1422-0067/17/8/1200

Internet

http://www.mdpi.com/1422-0067/17/8/1200

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