The In Vitro Replication, Spread, and Oncolytic Potential of Finnish Circulating Strains of Herpes Simplex Virus Type 1

The In Vitro Replication, Spread, and Oncolytic Potential of Finnish Circulating Strains of Herpes Simplex Virus Type 1

Herpes simplex virus type 1 (HSV-1) is the only FDA- and EMA- approved oncolytic virus, and accordingly, many potential oncolytic HSVs (oHSV) are in clinical development. The utilized oHSV parental strains are, however, mostly based on laboratory reference strains, which may possess a compromised cy...

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Bibliographic Details
Main Authors: Kiira Kalke, Julius Orpana, Tuomas Lasanen, Olaya Esparta, Liisa M. Lund, Fanny Frejborg, Tytti Vuorinen, Henrik Paavilainen, Veijo Hukkanen
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Viruses
Subjects:
herpes simplex virus type 1 (HSV-1)
oncolytic virus
oHSV
circulating strain
clinical isolate
phenotype
Online Access:https://www.mdpi.com/1999-4915/14/6/1290

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https://www.mdpi.com/1999-4915/14/6/1290

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