Upregulation of <i>Reg IV</i> and <i>Hgf</i> mRNAs by Intermittent Hypoxia via Downregulation of microRNA-499 in Cardiomyocytes

Upregulation of <i>Reg IV</i> and <i>Hgf</i> mRNAs by Intermittent Hypoxia via Downregulation of microRNA-499 in Cardiomyocytes

Sleep apnea syndrome (SAS) is characterized by recurrent episodes of oxygen desaturation and reoxygenation (intermittent hypoxia [IH]), and is a risk factor for cardiovascular disease (CVD) and insulin resistance/Type 2 diabetes. However, the mechanisms linking IH stress and CVD remain elusive. We e...

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Bibliographic Details
Main Authors: Shin Takasawa, Asako Itaya-Hironaka, Mai Makino, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Tomoko Uchiyama, Ryogo Shobatake, Yoshinori Takeda, Hiroyo Ota
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
intermittent hypoxia
sleep apnea syndrome
sustained hypoxia
Reg IV
HGF
microRNA-499
Online Access:https://www.mdpi.com/1422-0067/23/20/12414

Internet

https://www.mdpi.com/1422-0067/23/20/12414

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