“Orphan” Connexin43 in Plakophilin-2 Deficient Hearts Revealed by Volume Electron Microscopy

“Orphan” Connexin43 in Plakophilin-2 Deficient Hearts Revealed by Volume Electron Microscopy

Previous studies revealed an abundance of functional Connexin43 (Cx43) hemichannels consequent to loss of plakophilin-2 (PKP2) expression in adult murine hearts. The increased Cx43-mediated membrane permeability is likely responsible for excess entry of calcium into the cells, leading to an arrhythm...

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Bibliographic Details
Main Authors: Chantal J. M. van Opbergen, Joseph Sall, Chris Petzold, Kristen Dancel-Manning, Mario Delmar, Feng-Xia Liang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
arrhythmogenic right ventricular cardiomyopathy
plakophilin-2
serial block-face scanning electron microscopy
volume electron microscopy
connexin43 hemichannels
nanogold
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.843687/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.843687/full

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