MRI-derived brain iron, grey matter volume, and risk of dementia and Parkinson's disease: Observational and genetic analysis in the UK Biobank cohort

MRI-derived brain iron, grey matter volume, and risk of dementia and Parkinson's disease: Observational and genetic analysis in the UK Biobank cohort

Background: Iron overload is observed in neurodegenerative diseases, especially Alzheimer's disease (AD) and Parkinson's disease (PD). Homozygotes for the iron-overload (haemochromatosis) causing HFE p.C282Y variant have increased risk of dementia and PD. Whether brain iron deposition is c...

Full description

Bibliographic Details
Main Authors: Francesco Casanova, Qu Tian, Daniel S. Williamson, Yong Qian, David Zweibaum, Jun Ding, Janice L. Atkins, David Melzer, Luigi Ferrucci, Luke C. Pilling
Format: Article
Language:English
Published: Elsevier 2024-07-01
Series:Neurobiology of Disease
Subjects:
Iron
Dementia
Parkinson's
Genetics
Grey matter
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124001384

Internet

http://www.sciencedirect.com/science/article/pii/S0969996124001384

Similar Items