Effects of fadolmidine, an α2‐adrenoceptor agonist, as an adjuvant to spinal bupivacaine on antinociception and motor function in rats and dogs

Abstract α2‐Adrenoceptor agonists such as clonidine and dexmedetomidine are used as adjuvants to local anesthetics in regional anesthesia. Fadolmidine is an α2‐adrenoceptor agonist developed especially as a spinal analgesic. The current studies investigate the effects of intrathecally administered f...

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Bibliographic Details
Main Authors: Tiina Leino, Timo Viitamaa, Jarmo S. Salonen, Ullamari Pesonen, Antti Haapalinna
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:Pharmacology Research & Perspectives
Subjects:
Online Access:https://doi.org/10.1002/prp2.830