SARS-CoV-2 evolution in a patient with secondary B-cell immunodeficiency: A clinical case
The article highlights the course of long-term SARS-CoV-2 infection in a patient with a secondary immunodeficiency developed with B-cell-depleting therapy of the underlying disease. Analysis of the intrapatient virus evolution revealed an inpatient S:G75A mutation that alters the 72GTNGTKR78 motif o...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-11-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2022.2101334 |
| _version_ | 1797673150439227392 |
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| author | Olgo A. Mukhina Daria S. Fomina Vasiliy V. Parshin Vladimir A. Gushchin Inna V. Dolzhikova Alexey M. Shchetinin Dmitriy M. Chudakov Evgeniia Alekseeva Dmitriy Korostin Georgii A. Bazykin Galya Klink Denis Yu. Logunov Maryana A. Lysenko |
| author_facet | Olgo A. Mukhina Daria S. Fomina Vasiliy V. Parshin Vladimir A. Gushchin Inna V. Dolzhikova Alexey M. Shchetinin Dmitriy M. Chudakov Evgeniia Alekseeva Dmitriy Korostin Georgii A. Bazykin Galya Klink Denis Yu. Logunov Maryana A. Lysenko |
| author_sort | Olgo A. Mukhina |
| collection | DOAJ |
| description | The article highlights the course of long-term SARS-CoV-2 infection in a patient with a secondary immunodeficiency developed with B-cell-depleting therapy of the underlying disease. Analysis of the intrapatient virus evolution revealed an inpatient S:G75A mutation that alters the 72GTNGTKR78 motif of the S-protein, with a possible role in binding to alternative cellular receptors. Therapy with a ready-made COVID-19-globulin preparation (native human immunoglobulin G (IgG) derived from the plasma of convalescent COVID-19-patients) resulted in rapid improvement of the patient’s condition, fast, and stable elimination of the virus, and passive immunization of the patient for at least 30 days. The results suggest the use of products containing neutralizing antibodies opens new prospects for treatment algorithms for patients with persistent coronavirus infection, as well as for passive immunization schemes for patients with a presumably reduced specific response to vaccination. |
| first_indexed | 2024-03-11T21:40:20Z |
| format | Article |
| id | doaj.art-0304684f9fa34213ba942113eddce04b |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T21:40:20Z |
| publishDate | 2022-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-0304684f9fa34213ba942113eddce04b2023-09-26T13:19:08ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2022-11-0118610.1080/21645515.2022.21013342101334SARS-CoV-2 evolution in a patient with secondary B-cell immunodeficiency: A clinical caseOlgo A. Mukhina0Daria S. Fomina1Vasiliy V. Parshin2Vladimir A. Gushchin3Inna V. Dolzhikova4Alexey M. Shchetinin5Dmitriy M. Chudakov6Evgeniia Alekseeva7Dmitriy Korostin8Georgii A. Bazykin9Galya Klink10Denis Yu. Logunov11Maryana A. Lysenko12State Budgetary Healthcare Institution City Clinical HospitalState Budgetary Healthcare Institution City Clinical HospitalState Budgetary Healthcare Institution City Clinical HospitalFederal State Budgetary Institution “National Research Center for Epidemiology and Microbiology named after Honorary Academician N.-F. Gamaleya” of the Ministry of Health of the Russian FederationFederal State Budgetary Institution “National Research Center for Epidemiology and Microbiology named after Honorary Academician N.-F. Gamaleya” of the Ministry of Health of the Russian FederationFederal State Budgetary Institution “National Research Center for Epidemiology and Microbiology named after Honorary Academician N.-F. Gamaleya” of the Ministry of Health of the Russian FederationSkolkovo Institute of Science and TechnologySkolkovo Institute of Science and TechnologyPirogov Russian National Research Medical UniversitySkolkovo Institute of Science and TechnologyInstitute for Information Transmission Problems of the Russian Academy of Sciences (Kharkevich Institute)Federal State Budgetary Institution “National Research Center for Epidemiology and Microbiology named after Honorary Academician N.-F. Gamaleya” of the Ministry of Health of the Russian FederationState Budgetary Healthcare Institution City Clinical HospitalThe article highlights the course of long-term SARS-CoV-2 infection in a patient with a secondary immunodeficiency developed with B-cell-depleting therapy of the underlying disease. Analysis of the intrapatient virus evolution revealed an inpatient S:G75A mutation that alters the 72GTNGTKR78 motif of the S-protein, with a possible role in binding to alternative cellular receptors. Therapy with a ready-made COVID-19-globulin preparation (native human immunoglobulin G (IgG) derived from the plasma of convalescent COVID-19-patients) resulted in rapid improvement of the patient’s condition, fast, and stable elimination of the virus, and passive immunization of the patient for at least 30 days. The results suggest the use of products containing neutralizing antibodies opens new prospects for treatment algorithms for patients with persistent coronavirus infection, as well as for passive immunization schemes for patients with a presumably reduced specific response to vaccination.http://dx.doi.org/10.1080/21645515.2022.2101334immunodeficiencyb-cell depletionrituximabcoronavirus evolutioncovid-19sars-cov-2human immunoglobulinconvalescent plasmanormal human intravenous immunoglobulin |
| spellingShingle | Olgo A. Mukhina Daria S. Fomina Vasiliy V. Parshin Vladimir A. Gushchin Inna V. Dolzhikova Alexey M. Shchetinin Dmitriy M. Chudakov Evgeniia Alekseeva Dmitriy Korostin Georgii A. Bazykin Galya Klink Denis Yu. Logunov Maryana A. Lysenko SARS-CoV-2 evolution in a patient with secondary B-cell immunodeficiency: A clinical case Human Vaccines & Immunotherapeutics immunodeficiency b-cell depletion rituximab coronavirus evolution covid-19 sars-cov-2 human immunoglobulin convalescent plasma normal human intravenous immunoglobulin |
| title | SARS-CoV-2 evolution in a patient with secondary B-cell immunodeficiency: A clinical case |
| title_full | SARS-CoV-2 evolution in a patient with secondary B-cell immunodeficiency: A clinical case |
| title_fullStr | SARS-CoV-2 evolution in a patient with secondary B-cell immunodeficiency: A clinical case |
| title_full_unstemmed | SARS-CoV-2 evolution in a patient with secondary B-cell immunodeficiency: A clinical case |
| title_short | SARS-CoV-2 evolution in a patient with secondary B-cell immunodeficiency: A clinical case |
| title_sort | sars cov 2 evolution in a patient with secondary b cell immunodeficiency a clinical case |
| topic | immunodeficiency b-cell depletion rituximab coronavirus evolution covid-19 sars-cov-2 human immunoglobulin convalescent plasma normal human intravenous immunoglobulin |
| url | http://dx.doi.org/10.1080/21645515.2022.2101334 |
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