TPR is required for cytoplasmic chromatin fragment formation during senescence

TPR is required for cytoplasmic chromatin fragment formation during senescence

During oncogene-induced senescence there are striking changes in the organisation of heterochromatin in the nucleus. This is accompanied by activation of a pro-inflammatory gene expression programme – the senescence-associated secretory phenotype (SASP) – driven by transcription factors such as NF-κ...

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Bibliographic Details
Main Authors: Bethany M Bartlett, Yatendra Kumar, Shelagh Boyle, Tamoghna Chowdhury, Andrea Quintanilla, Charlene Boumendil, Juan Carlos Acosta, Wendy A Bickmore
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
genome integrity
senescence
nuclear periphery
oncogene
heterochromatin
inflammation
Online Access:https://elifesciences.org/articles/101702

Internet

https://elifesciences.org/articles/101702

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