DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity.
Errors in replication or segregation lead to DNA damage, mutations, and aneuploidies. Consequently, cells monitor these events and delay progression through the cell cycle so repair precedes division. The DNA damage response (DDR), which monitors DNA integrity, and the spindle assembly checkpoint (S...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-04-01
|
| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC4405263?pdf=render |