MYC up-regulation confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastoma

MYC up-regulation confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastoma

Abstract Background Medulloblastoma (MB) is the most common cerebellar malignancy during childhood. Among MB, MYC-amplified Group 3 tumors display the worst prognosis. MYC is an oncogenic transcription factor currently thought to be undruggable. Nevertheless, targeting MYC-dependent processes (i.e....

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Bibliographic Details
Main Authors: Consuelo Pitolli, Alberto Marini, Marika Guerra, Marco Pieraccioli, Veronica Marabitti, Fernando Palluzzi, Luciano Giacò, Gianpiero Tamburrini, Francesco Cecconi, Francesca Nazio, Claudio Sette, Vittoria Pagliarini
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
THZ531
RNA polymerase processivity
RNA processing regulation
Brain tumors
Chemotherapy resistance
Online Access:https://doi.org/10.1186/s13046-023-02790-2

Internet

https://doi.org/10.1186/s13046-023-02790-2

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