Preparation of Fibrinogen-Depleted Human Platelet Lysate to Support Heparin-Free Expansion of Umbilical Cord-Derived Mesenchymal Stem Cells

Preparation of Fibrinogen-Depleted Human Platelet Lysate to Support Heparin-Free Expansion of Umbilical Cord-Derived Mesenchymal Stem Cells

Human platelet lysate (hPL) has high levels of fibrinogen and coagulation factors, which can lead to gel and precipitate formation during storage and cell culture. Heparin derived from animals is commonly added to minimize these risks, but cannot completely eliminate them. Thus, this study proposes...

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Bibliographic Details
Main Authors: Li Ting Kee, Yi Ting Lee, Chiew Yong Ng, Muhammad Najib Fathi Hassan, Min Hwei Ng, Zalina Mahmood, Suria Abdul Aziz, Jia Xian Law
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Biology
Subjects:
human platelet lysate
calcium
fibrinogen
mesenchymal stem cell
cell culture
Online Access:https://www.mdpi.com/2079-7737/12/8/1085

Internet

https://www.mdpi.com/2079-7737/12/8/1085

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