Synthesis and anticancer evaluation of some novel pyrimido[5,4-e][1,2,4]triazines and pyrazolo[3,4-d]pyrimidine using DMF-DMA as methylating and cyclizing agent

Synthesis and anticancer evaluation of some novel pyrimido[5,4-e][1,2,4]triazines and pyrazolo[3,4-d]pyrimidine using DMF-DMA as methylating and cyclizing agent

Abstract Background Described a series of main target compounds pyrimido[5,4-e][1,2,4]triazines is obtained via condensation of 6-hydrazinyluracil with different aromatic aldehydes to give the hydrazones followed by nitrosation with HNO2 then intramolecular cyclization. On the other hand, pyrazolopy...

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Bibliographic Details
Main Author: Samar A. El-Kalyoubi
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Chemistry Central Journal
Subjects:
6-Hydrazinyluracil
Pyrimidotriazine
Pyrazolopyrimidine
Dimethylformamide-dimethylacetal
Anticancer activities
Online Access:http://link.springer.com/article/10.1186/s13065-018-0424-3

Internet

http://link.springer.com/article/10.1186/s13065-018-0424-3

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