Endothelin-1 as a Mediator of Heme Oxygenase-1-Induced Stemness in Colorectal Cancer: Influence of p53

Endothelin-1 as a Mediator of Heme Oxygenase-1-Induced Stemness in Colorectal Cancer: Influence of p53

Heme oxygenase-1 (HO-1) is an antioxidant protein implicated in tumor progression, metastasis, and resistance to therapy. Elevated HO-1 expression is associated with stemness in several types of cancer, although this aspect has not yet been studied in colorectal cancer (CRC). Using an in vitro model...

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Bibliographic Details
Main Authors: Sandra Ríos-Arrabal, Jose D. Puentes-Pardo, Sara Moreno-SanJuan, Ágata Szuba, Jorge Casado, María García-Costela, Julia Escudero-Feliu, Michela Verbeni, Carlos Cano, Cristina González-Puga, Alicia Martín-Lagos Maldonado, Ángel Carazo, Josefa León
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Journal of Personalized Medicine
Subjects:
colorectal cancer
cancer stem cells
heme oxygenase-1
endothelin-1
endothelin con-verting enzyme-1
bosentan
Online Access:https://www.mdpi.com/2075-4426/11/6/509

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https://www.mdpi.com/2075-4426/11/6/509

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