Inhibition of the NOTCH1 Pathway in the Stressed Heart Limits Fibrosis and Promotes Recruitment of Non-Myocyte Cells into the Cardiomyocyte Fate

Inhibition of the NOTCH1 Pathway in the Stressed Heart Limits Fibrosis and Promotes Recruitment of Non-Myocyte Cells into the Cardiomyocyte Fate

Cardiac pathologies lead to an acute or gradual loss of cardiomyocytes. Because of the limited regenerative capacity of the mammalian heart, cardiomyocytes are only replaced by fibrotic tissue. Excessive fibrosis contributes to the deterioration of cardiac function and the transition to heart failur...

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Bibliographic Details
Main Authors: Mohamed Nemir, Maryam Kay, Damien Maison, Corinne Berthonneche, Alexandre Sarre, Isabelle Plaisance, Thierry Pedrazzini
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
heart
remodeling
fibrosis
cardiomyocyte production
NOTCH
Online Access:https://www.mdpi.com/2308-3425/9/4/111

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https://www.mdpi.com/2308-3425/9/4/111

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