Enantiomeric Separation and Molecular Modelling of Bioactive 4-Aryl-3,4-dihydropyrimidin-2(1<i>H</i>)-one Ester Derivatives on Teicoplanin-Based Chiral Stationary Phase

Enantiomeric Separation and Molecular Modelling of Bioactive 4-Aryl-3,4-dihydropyrimidin-2(1<i>H</i>)-one Ester Derivatives on Teicoplanin-Based Chiral Stationary Phase

The enantiomeric separation of 15 racemic 4-aryl-3,4-dihydropyrimidin-2(1<i>H</i>)-one (DHP) alkoxycarbonyl esters, some of which proved to be highly active as A<sub>2B</sub> adenosine receptor antagonists, was carried out by HPLC on Chirobiotic<sup>TM</sup> TAG,...

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Bibliographic Details
Main Authors: Isabella Bolognino, Antonio Carrieri, Rosa Purgatorio, Marco Catto, Rocco Caliandro, Benedetta Carrozzini, Benny Danilo Belviso, Maria Majellaro, Eddy Sotelo, Saverio Cellamare, Cosimo Damiano Altomare
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Separations
Subjects:
4-aryl-3,4-dihydropyrimidin-2(1<i>H</i>)-ones
teicoplanin aglycone
chiral HPLC
enantioselectivity
molecular docking
molecular dynamics
Online Access:https://www.mdpi.com/2297-8739/9/1/7

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https://www.mdpi.com/2297-8739/9/1/7

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