RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection
Abstract Background Prion diseases and prion-like disorders, including Alzheimer’s disease and Parkinson’s disease, are characterized by gliosis and accumulation of misfolded aggregated host proteins. Ablating microglia in prion-infected brain by treatment with the colony-stimulating factor-1 recept...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-05-01
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Series: | Molecular Brain |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13041-020-00610-8 |