RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection

Abstract Background Prion diseases and prion-like disorders, including Alzheimer’s disease and Parkinson’s disease, are characterized by gliosis and accumulation of misfolded aggregated host proteins. Ablating microglia in prion-infected brain by treatment with the colony-stimulating factor-1 recept...

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Bibliographic Details
Main Authors: James A. Carroll, Brent Race, Katie Williams, James Striebel, Bruce Chesebro
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Molecular Brain
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13041-020-00610-8