Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice

Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice

PEGylated-l-asparaginase (PEG-ASNase) is a chemotherapeutic agent used to treat pediatric acute lymphoblastic leukemia (ALL). Its use is avoided in adults due to its high risk of liver injury including hepatic steatosis, with obesity and older age considered risk factors of the injury. Our study aim...

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Bibliographic Details
Main Authors: Gundala Venkata Naveen Kumar, Keito Hoshitsuki, Sanjay Rathod, Manda J. Ramsey, Lauren Kokai, Erin E. Kershaw, Wen Xie, Christian A. Fernandez
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Liver injury
Leukemia
Asparaginase
Lipolysis
Adverse drug reaction
Adipose tissue
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521004603

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http://www.sciencedirect.com/science/article/pii/S2211383521004603

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