A genome-wide CRISPR screening uncovers that TOB1 acts as a key host factor for FMDV infection via both IFN and EGFR mediated pathways.

A genome-wide CRISPR screening uncovers that TOB1 acts as a key host factor for FMDV infection via both IFN and EGFR mediated pathways.

The interaction between foot-and-mouth disease virus (FMDV) and the host is extremely important for virus infection, but there are few researches on it, which is not conducive to vaccine development and FMD control. In this study, we designed a porcine genome-scale CRISPR/Cas9 knockout library conta...

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Bibliographic Details
Main Authors: Gaochuang Peng, Tianran Liu, Xiaolan Qi, Yuzhe Wang, Jingjing Ren, Jiangling Peng, Xuguang Du, Siyu Hu, Sen Wu, Yaofeng Zhao, Dan Li, Haixue Zheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012104

Internet

https://doi.org/10.1371/journal.ppat.1012104

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