Investigation of the potential effects of estrogen receptor modulators on immune checkpoint molecules

Investigation of the potential effects of estrogen receptor modulators on immune checkpoint molecules

Abstract Immune checkpoints regulate the immune system response. Recent studies suggest that flavonoids, known as phytoestrogens, may inhibit the PD-1/PD-L1 axis. We explored the potential of estrogens and 17 Selective Estrogen Receptor Modulators (SERMs) as inhibiting ligands for immune checkpoint...

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Bibliographic Details
Main Authors: Nikita Abramenko, Fréderic Vellieux, Kateřina Veselá, Zdeněk Kejík, Jan Hajduch, Michal Masařík, Petr Babula, David Hoskovec, Karel Pacák, Pavel Martásek, Karel Smetana, Milan Jakubek
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-51804-2

Internet

https://doi.org/10.1038/s41598-024-51804-2

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