Pharmacologic antagonism of CB1 receptors improves electrophysiological alterations in Purkinje cells exposed to 3-AP

Pharmacologic antagonism of CB1 receptors improves electrophysiological alterations in Purkinje cells exposed to 3-AP

Highlights Purkinje cell excitability dramatically increased after exposure to 3-AP. 3-AP caused a significant decrease in ISI, half-width, and first spike latency. CB1R antagonist attenuated the cellular effects of 3-AP. AM251 reduced the excitability of Purkinje cells exposed to 3-AP.

Bibliographic Details
Main Authors: Hoda Ranjbar, Monavareh Soti, Kristi A. Kohlmeier, Mahyar Janahmadi, Mohammad Shabani
Format: Article
Language:English
Published: BMC 2023-03-01
Series:BMC Neuroscience
Subjects:
Ataxia
Cerebellum
Purkinje cell
Cannabinoid
CB1R
Online Access:https://doi.org/10.1186/s12868-023-00786-4

Internet

https://doi.org/10.1186/s12868-023-00786-4

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