Pharmacologic antagonism of CB1 receptors improves electrophysiological alterations in Purkinje cells exposed to 3-AP
Highlights Purkinje cell excitability dramatically increased after exposure to 3-AP. 3-AP caused a significant decrease in ISI, half-width, and first spike latency. CB1R antagonist attenuated the cellular effects of 3-AP. AM251 reduced the excitability of Purkinje cells exposed to 3-AP.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-03-01
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| Series: | BMC Neuroscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12868-023-00786-4 |
| _version_ | 1797865447292403712 |
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| author | Hoda Ranjbar Monavareh Soti Kristi A. Kohlmeier Mahyar Janahmadi Mohammad Shabani |
| author_facet | Hoda Ranjbar Monavareh Soti Kristi A. Kohlmeier Mahyar Janahmadi Mohammad Shabani |
| author_sort | Hoda Ranjbar |
| collection | DOAJ |
| description | Highlights Purkinje cell excitability dramatically increased after exposure to 3-AP. 3-AP caused a significant decrease in ISI, half-width, and first spike latency. CB1R antagonist attenuated the cellular effects of 3-AP. AM251 reduced the excitability of Purkinje cells exposed to 3-AP. |
| first_indexed | 2024-04-09T23:08:55Z |
| format | Article |
| id | doaj.art-0315faaf8e6643a4b49ed539772620e5 |
| institution | Directory Open Access Journal |
| issn | 1471-2202 |
| language | English |
| last_indexed | 2024-04-09T23:08:55Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neuroscience |
| spelling | doaj.art-0315faaf8e6643a4b49ed539772620e52023-03-22T10:31:11ZengBMCBMC Neuroscience1471-22022023-03-0124111110.1186/s12868-023-00786-4Pharmacologic antagonism of CB1 receptors improves electrophysiological alterations in Purkinje cells exposed to 3-APHoda Ranjbar0Monavareh Soti1Kristi A. Kohlmeier2Mahyar Janahmadi3Mohammad Shabani4Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical SciencesNeuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical SciencesDepartment of Drug Design and Pharmacology, Faculty of Health Sciences, University of CopenhagenDepartment of Physiology, School of Medicine, Shahid Beheshti University of Medical SciencesNeuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical SciencesHighlights Purkinje cell excitability dramatically increased after exposure to 3-AP. 3-AP caused a significant decrease in ISI, half-width, and first spike latency. CB1R antagonist attenuated the cellular effects of 3-AP. AM251 reduced the excitability of Purkinje cells exposed to 3-AP.https://doi.org/10.1186/s12868-023-00786-4AtaxiaCerebellumPurkinje cellCannabinoidCB1R |
| spellingShingle | Hoda Ranjbar Monavareh Soti Kristi A. Kohlmeier Mahyar Janahmadi Mohammad Shabani Pharmacologic antagonism of CB1 receptors improves electrophysiological alterations in Purkinje cells exposed to 3-AP BMC Neuroscience Ataxia Cerebellum Purkinje cell Cannabinoid CB1R |
| title | Pharmacologic antagonism of CB1 receptors improves electrophysiological alterations in Purkinje cells exposed to 3-AP |
| title_full | Pharmacologic antagonism of CB1 receptors improves electrophysiological alterations in Purkinje cells exposed to 3-AP |
| title_fullStr | Pharmacologic antagonism of CB1 receptors improves electrophysiological alterations in Purkinje cells exposed to 3-AP |
| title_full_unstemmed | Pharmacologic antagonism of CB1 receptors improves electrophysiological alterations in Purkinje cells exposed to 3-AP |
| title_short | Pharmacologic antagonism of CB1 receptors improves electrophysiological alterations in Purkinje cells exposed to 3-AP |
| title_sort | pharmacologic antagonism of cb1 receptors improves electrophysiological alterations in purkinje cells exposed to 3 ap |
| topic | Ataxia Cerebellum Purkinje cell Cannabinoid CB1R |
| url | https://doi.org/10.1186/s12868-023-00786-4 |
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