The Effect of Fat Intake with Increased Omega-6-to-Omega-3 Polyunsaturated Fatty Acid Ratio in Animal Models of Early and Late Alzheimer’s Disease-like Pathogenesis

The Effect of Fat Intake with Increased Omega-6-to-Omega-3 Polyunsaturated Fatty Acid Ratio in Animal Models of Early and Late Alzheimer’s Disease-like Pathogenesis

This work aims to clarify the effect of dietary polyunsaturated fatty acid (PUFA) intake on the adult brain affected by amyloid pathology. McGill-R-Thy1-APP transgenic (Tg) rat and 5xFAD Tg mouse models that represent earlier or later disease stages were employed. The animals were exposed to a contr...

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Bibliographic Details
Main Authors: Pablo Galeano, Marialuisa de Ceglia, Mauricio Mastrogiovanni, Lorenzo Campanelli, Dina Medina-Vera, Nicolás Campolo, Gisela V. Novack, Cristina Rosell-Valle, Juan Suárez, Adrián Aicardo, Karen Campuzano, Eduardo M. Castaño, Sonia Do Carmo, A. Claudio Cuello, Silvina Bartesaghi, Rafael Radi, Fernando Rodríguez de Fonseca, Laura Morelli
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
nutrition
high fat diet
PUFA
omega-3/omega-6
Alzheimer’s disease
transgenic animals
Online Access:https://www.mdpi.com/1422-0067/24/23/17009

Internet

https://www.mdpi.com/1422-0067/24/23/17009

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