Fine particulate matter exposure disturbs autophagy, redox balance and mitochondrial homeostasis via JNK activation to inhibit proliferation and promote EMT in human alveolar epithelial A549 cells

Fine particulate matter exposure disturbs autophagy, redox balance and mitochondrial homeostasis via JNK activation to inhibit proliferation and promote EMT in human alveolar epithelial A549 cells

Epidemiologic studies have demonstrated a direct correlation between fine particulate matter (FPM) exposure and the high risk of respiratory diseases. FPM can penetrate deep into the lung and deposit in the alveoli with breath, where it directly interacts with alveolar epithelial cell (APC). However...

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Bibliographic Details
Main Authors: Yan Wang, Ying Li, Yilin Gao, Jiahao Kang, Weijia Wang, Yu-Le Yong, Xiaoyan Qu, Xiaomin Dang, Dong Shang, Yongping Shao, Jiankang Liu, Ying Chang, Lin Zhao
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
FPM
LC3II
ROS
Mitochondrial fragmentation
Oxygen consumption rate
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323006383

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http://www.sciencedirect.com/science/article/pii/S0147651323006383

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