Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp. c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1α/XBP-1s axis and JNK signaling

Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp. c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1α/XBP-1s axis and JNK signaling

Lipotoxicity is a pivotal factor that initiates and exacerbates liver injury and is involved in the development of metabolic-associated fatty liver disease (MAFLD). However, there are few reported lipotoxicity inhibitors. Here, we identified a natural anti-lipotoxicity candidate, HN-001, from the ma...

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Bibliographic Details
Main Authors: Yong Rao, Rui Su, Chenyan Wu, Xingxing Chai, Jinjian Li, Guanyu Yang, Junjie Wu, Tingting Fu, Zhongping Jiang, Zhikai Guo, Congjun Xu, Ling Huang
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Lipotoxicity
MAFLD
ER stress
IRE-1α
XBP-1s
JNK
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523003398

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http://www.sciencedirect.com/science/article/pii/S2211383523003398

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