Composites of Nucleic Acids and Boron Clusters (C<sub>2</sub>B<sub>10</sub>H<sub>12</sub>) as Functional Nanoparticles for Downregulation of EGFR Oncogene in Cancer Cells

Composites of Nucleic Acids and Boron Clusters (C<sub>2</sub>B<sub>10</sub>H<sub>12</sub>) as Functional Nanoparticles for Downregulation of EGFR Oncogene in Cancer Cells

Epidermal growth factor receptor (EGFR) is one of the most promising molecular targets for anticancer therapy. We used boron clusters as a platform for generation of new materials. For this, functional DNA constructs conjugated with boron clusters (B-ASOs) were developed. These B-ASOs, built from 1,...

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Bibliographic Details
Main Authors: Damian Kaniowski, Katarzyna Ebenryter-Olbińska, Katarzyna Kulik, Justyna Suwara, Wojciech Cypryk, Agata Jakóbik-Kolon, Zbigniew Leśnikowski, Barbara Nawrot
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
antisense oligonucleotide
boron cluster
nanostructure
EGFR
macrophages
cellular uptake
Online Access:https://www.mdpi.com/1422-0067/22/9/4863

Internet

https://www.mdpi.com/1422-0067/22/9/4863

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