Influence of a genetic variant of CHAT gene over the profile of plasma soluble ChAT in Alzheimer disease

Influence of a genetic variant of CHAT gene over the profile of plasma soluble ChAT in Alzheimer disease

Abstract The choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) are fundamental to neurophysiological functions of the central cholinergic system. We confirmed and quantified the presence of extracellular ChAT protein in human plasma and also characterized ChAT and VACh...

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Bibliographic Details
Main Authors: Patricia Fernanda Rocha-Dias, Daiane Priscila Simao-Silva, Saritha Suellen Lopes da Silva, Mauro Roberto Piovezan, Ricardo Krause M. Souza, Taher. Darreh-Shori, Lupe Furtado-Alle, Ricardo Lehtonen Rodrigues Souza
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2020-11-01
Series:Genetics and Molecular Biology
Subjects:
ChAT
VAChT
dementia
cholinergic dysfunction
peripheral cholinergic signaling
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000600107&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000600107&tlng=en

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