PHD2 safeguards modest mesendoderm development
Abstract PHD2 is essential in modulating HIF-1α levels upon oxygen fluctuations. Hypoxia, a hallmark of uterus, and HIF-1α have recently emerged as opposing regulators of mesendoderm specification, suggesting a role for PHD2 therein. We found that PHD2 expression initially covered the epiblast and g...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-09-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-06824-z |