Expression of Tumor-mediated CD137 ligand in human colon cancer indicates dual signaling effects

Expression of Tumor-mediated CD137 ligand in human colon cancer indicates dual signaling effects

CD137-targeting immune therapy, which activates anti-tumor T effector cell responses, seems to be an attractive concept in clinical oncology. Recent evidence has demonstrated that tumor cells besides T cells and antigen-presenting cells are able to express CD137 and CD137L. Here we aimed to identify...

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Bibliographic Details
Main Authors: Tanja Grimmig, Martin Gasser, Romana Moench, Lang-Jing Zhu, Karol Nawalaniec, Simone Callies, Martin Wagner, Buelent Polat, Suraj Sarvode Mothi, Yueming Luo, Carmen M. Ribas, Osvaldo Malafaia, Li-Li Hsiao, Ana Maria Waaga-Gasser
Format: Article
Language:English
Published: Taylor & Francis Group 2019-12-01
Series:OncoImmunology
Subjects:
cd137/cd137l pathway
anti-tumor immune response
co-stimulatory signaling
tumor escape mechanism
colorectal cancer
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1651622

Internet

http://dx.doi.org/10.1080/2162402X.2019.1651622

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