Assessment of topoisomerase II-alpha gene status by dual color chromogenic in situ hybridization in a set of Iraqi patients with invasive breast carcinoma

Assessment of topoisomerase II-alpha gene status by dual color chromogenic in situ hybridization in a set of Iraqi patients with invasive breast carcinoma

Background: The human epidermal growth factor receptor 2(HER2) proto-oncogene is overexpressed or amplified in approximately 15%–25% of invasive breast cancers. Approximately 35% of HER2-amplified breast cancers have coamplification of the topoisomerase II-alpha (TOP2A) gene encoding an enzyme that...

Full description

Bibliographic Details
Main Authors: Rasha Abd Alraouf Neama, Manal A Habib, Sahira A Ali, Ali H Al-Khafaji, Mohammed F Alqanbar
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:Indian Journal of Pathology and Microbiology
Subjects:
Breast cancer
dual-color chromogenic in situ hybridization
human epidermal growth factor receptor 2/neu
topoisomerase II-alpha gene
Online Access:http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2017;volume=60;issue=4;spage=475;epage=480;aulast=Neama

Internet

http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2017;volume=60;issue=4;spage=475;epage=480;aulast=Neama

Similar Items