Single-cell heterogeneity and dynamic evolution of Ph-like acute lymphoblastic leukemia patient with novel TPR-PDGFRB fusion gene

Single-cell heterogeneity and dynamic evolution of Ph-like acute lymphoblastic leukemia patient with novel TPR-PDGFRB fusion gene

Abstract Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a refractory and recurrent subtype of B-cell ALL enriched with kinase-activating rearrangements. Incomplete understanding of the heterogeneity within the tumor cells presents a major challenge for the diagnosis and t...

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Bibliographic Details
Main Authors: Xuehong Zhang, Zhijie Hou, Dan Huang, Furong Wang, Beibei Gao, Chengtao Zhang, Dong Zhou, Jiacheng Lou, Haina Wang, Yuan Gao, Zhijie Kang, Ying Lu, Quentin Liu, Jinsong Yan
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Experimental Hematology & Oncology
Subjects:
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL)
Fusion gene
Single-cell RNA sequencing (scRNA-seq)
Cellular heterogeneity
Immunotherapy
Online Access:https://doi.org/10.1186/s40164-023-00380-8

Internet

https://doi.org/10.1186/s40164-023-00380-8

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