Investigation of anti-diabetic potential and molecular simulation studies of dihydropyrimidinone derivatives

In an attempt to find new targets for α-amylase and α-glucosidase for the treatment of type 2 diabetes mellitus, the present study aims in determining the anti-diabetic potential of synthesized dihydropyrimidinone derivatives. The in vitro α-glucosidase and α-amylase inhibitory activity was performe...

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Bibliographic Details
Main Authors: Umair Ilyas, Bisma Nazir, Reem Altaf, Syed Aun Muhammad, Hajra Zafar, Ana Cláudia Paiva-Santos, Muhammad Abbas, Yongtao Duan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Endocrinology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.1022623/full