A diverse ancestrally-matched reference panel increases genotype imputation accuracy in a underrepresented population

A diverse ancestrally-matched reference panel increases genotype imputation accuracy in a underrepresented population

Abstract Variant imputation, a common practice in genome-wide association studies, relies on reference panels to infer unobserved genotypes. Multiple public reference panels are currently available with variations in size, sequencing depth, and represented populations. Currently, limited data exist...

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Bibliographic Details
Main Authors: John Mauleekoonphairoj, Sissades Tongsima, Apichai Khongphatthanayothin, Sean J. Jurgens, Dominic S. Zimmerman, Boosamas Sutjaporn, Pharawee Wandee, Connie R. Bezzina, Koonlawee Nademanee, Yong Poovorawan
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-39429-3

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