Mixed-Lineage Leukemia 1 Inhibition Enhances the Differentiation Potential of Bovine Embryonic Stem Cells by Increasing H3K4 Mono-Methylation at Active Promoters

Mixed-Lineage Leukemia 1 Inhibition Enhances the Differentiation Potential of Bovine Embryonic Stem Cells by Increasing H3K4 Mono-Methylation at Active Promoters

Mixed-lineage leukemia 1 (MLL1) introduces 1-, 2- and 3-methylation into histone H3K4 through the evolutionarily conserved set domain. In this study, bovine embryonic stem cells (bESCs, known as bESCs-F7) were established from in vitro-fertilized (IVF) embryos via Wnt signaling inhibition; however,...

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Bibliographic Details
Main Authors: Chen Li, Xuejie Han, Jing Wang, Fang Liu, Yuanyuan Zhang, Zihong Li, Zhenyu Lu, Yongli Yue, Jinzhu Xiang, Xueling Li
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
bovine embryonic stem cells (bESCs)
pluripotent
H3K4me1 modification
DNA methylation modification
Online Access:https://www.mdpi.com/1422-0067/24/15/11901

Internet

https://www.mdpi.com/1422-0067/24/15/11901

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