Designed Ankyrin Repeat Proteins: A New Class of Viral Entry Inhibitors

Designed Ankyrin Repeat Proteins: A New Class of Viral Entry Inhibitors

Designed ankyrin repeat proteins (DARPins) are engineered proteins comprising consensus designed ankyrin repeats as scaffold. Tightly packed repeats form a continuous hydrophobic core and a large groove-like solvent-accessible surface that creates a binding surface. DARPin domains recognizing a targ...

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Bibliographic Details
Main Authors: Marcel Walser, Jennifer Mayor, Sylvia Rothenberger
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Viruses
Subjects:
ankyrin repeat protein
protein scaffold
protein design
DARPin
antiviral therapy
multispecificity
Online Access:https://www.mdpi.com/1999-4915/14/10/2242

Internet

https://www.mdpi.com/1999-4915/14/10/2242

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