Template Entrance Channel as Possible Allosteric Inhibition and Resistance Site for Quinolines Tricyclic Derivatives in RNA Dependent RNA Polymerase of Bovine Viral Diarrhea Virus

Template Entrance Channel as Possible Allosteric Inhibition and Resistance Site for Quinolines Tricyclic Derivatives in RNA Dependent RNA Polymerase of Bovine Viral Diarrhea Virus

The development of potent non-nucleoside inhibitors (NNIs) could be an alternate strategy to combating infectious bovine viral diarrhea virus (BVDV), other than the traditional vaccination. RNA-dependent RNA polymerase (RdRp) is an essential enzyme for viral replication; therefore, it is one of the...

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Bibliographic Details
Main Authors: Mitul Srivastava, Lovika Mittal, Debapriyo Sarmadhikari, Vijay Kumar Singh, Antonella Fais, Amit Kumar, Shailendra Asthana
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pharmaceuticals
Subjects:
bovine viral diarrhea virus (BVDV)
RNA-dependent RNA polymerase (RdRp)
BVDV inhibitor
molecular dynamics simulations
free energy calculations
metadynamics
Online Access:https://www.mdpi.com/1424-8247/16/3/376

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https://www.mdpi.com/1424-8247/16/3/376

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