Heme-Induced Oxidation of Cysteine Groups of Myofilament Proteins Leads to Contractile Dysfunction of Permeabilized Human Skeletal Muscle Fibres

Heme-Induced Oxidation of Cysteine Groups of Myofilament Proteins Leads to Contractile Dysfunction of Permeabilized Human Skeletal Muscle Fibres

Heme released from red blood cells targets a number of cell components including the cytoskeleton. The purpose of the present study was to determine the impact of free heme (20–300 µM) on human skeletal muscle fibres made available during orthopedic surgery. Isometric force production and oxidative...

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Bibliographic Details
Main Authors: Gerardo Alvarado, Attila Tóth, Éva Csősz, Gergő Kalló, Katalin Dankó, Zoltán Csernátony, Ann Smith, Magnus Gram, Bo Akerström, István Édes, György Balla, Zoltán Papp, József Balla
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
skeletal muscle fibre
contractile dysfunction
heme
sulfhydryl groups
sulfenic acid formation
chronic heart failure
Online Access:https://www.mdpi.com/1422-0067/21/21/8172

Internet

https://www.mdpi.com/1422-0067/21/21/8172

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