Pyrenebutyrate Pt(IV) Complexes with Nanomolar Anticancer Activity

Pyrenebutyrate Pt(IV) Complexes with Nanomolar Anticancer Activity

Research on platinum-based anticancer drugs continuously strives to develop new non-classical platinum complexes. Pt(IV) prodrugs are the most promising, and their activation-by-reduction mechanism of action is being explored as a prospect for higher selectivity and efficiency. Herein, we present th...

Full description

Bibliographic Details
Main Authors:	Anife Ahmedova, Rositsa Mihaylova, Silviya Stoykova, Veronika Mihaylova, Nikola Burdzhiev, Viktoria Elincheva, Georgi Momekov, Denitsa Momekova
Format:	Article
Language:	English
Published:	MDPI AG 2023-09-01
Series:	Pharmaceutics
Subjects:	platinum(IV) prodrugs anticancer agents cytotoxicity cellular uptake activation by reduction
Online Access:	https://www.mdpi.com/1999-4923/15/9/2310

Similar Items

Immunoconjugates as an Efficient Platform for Drug Delivery: A Resurgence of Natural Products in Targeted Antitumor Therapy
by: Rositsa Mihaylova, et al.
Published: (2024-12-01)

Cyclooxygenase-Inhibiting Platinum(IV) Prodrugs with Potent Anticancer Activity
by: Aleen Khoury, et al.
Published: (2022-04-01)

Engineering Novel Amphiphilic Platinum(IV) Complexes to Co-Deliver Cisplatin and Doxorubicin
by: Wjdan Jogadi, et al.
Published: (2024-08-01)

Influence of the Fatty Acid Metabolism on the Mode of Action of a Cisplatin(IV) Complex with Phenylbutyrate as Axial Ligands
by: Theresa Mendrina, et al.
Published: (2023-02-01)

Novel Pt(IV) prodrug self-assembled nanoparticles with enhanced blood circulation stability and improved antitumor capacity of oxaliplatin for cancer therapy
by: Yuanlei Fu, et al.
Published: (2023-12-01)

Photoactivatable Platinum-Based Anticancer Drugs: Mode of Photoactivation and Mechanism of Action
by: Ziwen Dai, et al.
Published: (2020-11-01)

Oxidation of the Platinum(II) Anticancer Agent [Pt{(<i>p</i>-BrC<sub>6</sub>F<sub>4</sub>)NCH<sub>2</sub>CH<sub>2</sub>NEt<sub>2</sub>}Cl(py)] to Platinum(IV) Complexes by Hydrogen Peroxide
by: Ruchika Ojha, et al.
Published: (2023-09-01)

Combination of Drug Delivery Properties of PAMAM Dendrimers and Cytotoxicity of Platinum(IV) Complexes—A More Selective Anticancer Treatment?
by: Yvonne Lerchbammer-Kreith, et al.
Published: (2023-05-01)

Synthesis, Characterization and Host-Guest Complexation of Asplatin: Improved In Vitro Cytotoxicity and Biocompatibility as Compared to Cisplatin
by: Sherif Ashraf Fahmy, et al.
Published: (2022-02-01)

Quaternary Ammonium Palmitoyl Glycol Chitosan (GCPQ) Loaded with Platinum-Based Anticancer Agents—A Novel Polymer Formulation for Anticancer Therapy
by: Yvonne Lerchbammer-Kreith, et al.
Published: (2023-07-01)

<sup>13</sup>C CPMAS NMR as a Tool for Full Structural Description of 2-Phenyl Substituted Imidazoles That Overcomes the Effects of Fast Tautomerization
by: Nikola Burdzhiev, et al.
Published: (2020-08-01)

Mesoporous Silica Nanoparticles Enhance the Anticancer Efficacy of Platinum(IV)-Phenolate Conjugates in Breast Cancer Cell Lines
by: Ivana Predarska, et al.
Published: (2022-10-01)

Unveiling the chemotherapeutic potential of two platinum(IV) complexes in skin cancer: in vitro and in vivo Insights
by: Amjad Slika, et al.
Published: (2024-01-01)

Novel Pt(IV) complex OAP2 induces STING activation and pyroptosis via mitochondrial membrane remodeling for synergistic chemo-immunotherapy
by: Renming Fan, et al.
Published: (2024-04-01)

Prodrug Approach: NSAID Conjugates of Platinum Compounds as Anti-Cancer Agents
by: NIJA B
Published: (2023-12-01)

The Challenging Treatment of Cisplatin-Resistant Tumors: State of the Art and Future Perspectives
by: Giulia Coffetti, et al.
Published: (2023-04-01)

Application of Response Surface Methodology for Optimization of Platinum(IV) Adsorption Using Magnetic Cellulose Nanoparticles Modified with Ethylenediamine
by: M. Anbia, et al.
Published: (2016-10-01)

Platinum(IV)-Loaded Degraded Glycol Chitosan as Efficient Platinum(IV) Drug Delivery Platform
by: Yvonne Lerchbammer-Kreith, et al.
Published: (2023-03-01)

Formulation and Evaluation of Hybrid Niosomal In Situ Gel for Intravesical Co-Delivery of Curcumin and Gentamicin Sulfate
by: Viliana Gugleva, et al.
Published: (2022-03-01)

Unsymmetric Cisplatin-Based Pt(IV) Conjugates Containing a PARP-1 Inhibitor Pharmacophore Tested on Malignant Pleural Mesothelioma Cell Lines
by: Elisabetta Gabano, et al.
Published: (2021-08-01)

Design, Synthesis, and Evaluation of Doxifluridine Derivatives as Nitroreductase-Responsive Anticancer Prodrugs
by: Xinmeng Zhang, et al.
Published: (2024-10-01)

Studies on the Formation of Catalytically Active PGM Nanoparticles from Model Solutions as a Basis for the Recycling of Spent Catalysts
by: Martyna Rzelewska-Piekut, et al.
Published: (2022-01-01)

Synthesis and Characterization of A New Ligand (DPTYEDAPIBO) Derived from 2-Aminothiazole and Preliminary MCF-7 Cytotoxicity Evaluation
by: Abbas Fadhil Yasir, et al.
Published: (2024-06-01)

Synthesis, Characterization, Luminescent Properties, And Crystal Structure Determination Of a New Platinium (IV) Complexe : trans-[Pt(4-mpy)2Cl4]
by: Naghmeh FaalHamedani, et al.
Published: (2019-12-01)

Design, Synthesis and Anticancer Evaluation of Nitroimidazole Radiosensitisers
by: Lydia P. Liew, et al.
Published: (2023-05-01)

Polysaccharide Cryogels Containing β-Cyclodextrin for the Delivery of Cannabidiol
by: Denitsa Momekova, et al.
Published: (2021-10-01)

Pharmacological Activities of Schiff Bases and Their Derivatives with Low and High Molecular Phosphonates
by: Ivelina Tsacheva, et al.
Published: (2023-06-01)

Current Trends in Clinical Trials of Prodrugs
by: Diogo Boreski, et al.
Published: (2025-02-01)

Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents
by: Ziad Omran, et al.
Published: (2021-06-01)

Nanoparticle Targeting in Chemo‐Resistant Ovarian Cancer Reveals Dual Axis of Therapeutic Vulnerability Involving Cholesterol Uptake and Cell Redox Balance
by: Yinu Wang, et al.
Published: (2024-04-01)

Colorimetric detection of platinum (IV) ions based on triangular silver nanoprism particles in aqueous environmental sample
by: Ko Jeong Won, et al.
Published: (2024-09-01)

Pt(IV) anticancer prodrugs and liposomal encapsulation
by: Marsh, L
Published: (2022)

Arylnaphthalene lignans with a focus Linum species: a review on phytochemical, biotechnological and pharmacological potential
by: Rada Nedelcheva, et al.
Published: (2024-02-01)

Peptide-Based Bioconjugates and Therapeutics for Targeted Anticancer Therapy
by: Seong-Bin Yang, et al.
Published: (2022-06-01)

Hypoxia-activated small molecule-induced gene expression
by: Collins, S
Published: (2018)

Preparation one of prodrug and study its effect on some biochemical parameters at blood serum
by: F. S. Abdul-Razzak, et al.
Published: (2016-12-01)

Logam-logam platinum/
by: 237959 Misliah Masari

Emerging Albumin-Binding Anticancer Drugs for Tumor-Targeted Drug Delivery: Current Understandings and Clinical Translation
by: Hanhee Cho, et al.
Published: (2022-03-01)

Unraveling Novel Strategies in Mesothelioma Treatments Using a Newly Synthetized Platinum(IV) Compound
by: Cristina Favaron, et al.
Published: (2024-07-01)

AGENTES ANTINEOPLÁSICOS BIORREDUTÍVEIS: AVANÇOS E DESAFIOS APÓS 20 ANOS
by: Pedro A. L. Santana, et al.
Published: (2024-03-01)