Nonclinical characterization of ICVB-1042 as a selective oncolytic adenovirus for solid tumor treatment
Abstract ICVB-1042 is an oncolytic adenovirus containing modifications to enhance replication, lysis, and viral spreading in tumor cells. The anti-tumor activity, immune activation, tropism, selectivity, and mechanism of action were evaluated in preparation for a first-in-human study. ICVB-1042 was...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-09-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-06839-6 |