Vector-mediated PTEN deletion in the adult dentate gyrus initiates new growth of granule cell bodies and dendrites and expansion of mossy fiber terminal fields that continues for months

Vector-mediated PTEN deletion in the adult dentate gyrus initiates new growth of granule cell bodies and dendrites and expansion of mossy fiber terminal fields that continues for months

Embryonic and early postnatal deletion of the gene phosphatase and tensin homolog (PTEN) results in neuronal hypertrophy, formation of aberrant neural networks and spontaneous seizures. Our previous studies document that deletion of PTEN in mature neurons also causes growth of cortical neuron cell b...

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Bibliographic Details
Main Authors: Jennifer M. Yonan, Oswald Steward
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Neurobiology of Disease
Subjects:
PTEN
mTOR
Dentate gyrus
Hippocampus
Granule cells
Entorhinal cortex
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612300205X

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http://www.sciencedirect.com/science/article/pii/S096999612300205X

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