Role of the Circadian Clock “Death-Loop” in the DNA Damage Response Underpinning Cancer Treatment Resistance

Role of the Circadian Clock “Death-Loop” in the DNA Damage Response Underpinning Cancer Treatment Resistance

Here, we review the role of the circadian clock (CC) in the resistance of cancer cells to genotoxic treatments in relation to whole-genome duplication (WGD) and telomere-length regulation. The CC drives the normal cell cycle, tissue differentiation, and reciprocally regulates telomere elongation. Ho...

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Bibliographic Details
Main Authors: Ninel Miriam Vainshelbaum, Kristine Salmina, Bogdan I. Gerashchenko, Marija Lazovska, Pawel Zayakin, Mark Steven Cragg, Dace Pjanova, Jekaterina Erenpreisa
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
cancer resistance
genotoxic treatments
circadian clock (CC)
cell cycle
DNA damage response (DDR)
reversible polyploidy
Online Access:https://www.mdpi.com/2073-4409/11/5/880

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https://www.mdpi.com/2073-4409/11/5/880

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