NEDDylation antagonizes ubiquitination of proliferating cell nuclear antigen and regulates the recruitment of polymerase η in response to oxidative DNA damage

NEDDylation antagonizes ubiquitination of proliferating cell nuclear antigen and regulates the recruitment of polymerase η in response to oxidative DNA damage

ABSTRACT NEDDylation has been shown to participate in the DNA damage pathway, but the substrates of neural precursor cell expressed developmentally downregulated 8 (NEDD8) and the roles of NEDDylation involved in the DNA damage response (DDR) are largely unknown. Translesion synthesis (TLS) is a dam...

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Bibliographic Details
Main Authors: Junhong Guan, Shuyu Yu, Xiaofeng Zheng
Format: Article
Language:English
Published: Oxford University Press 2017-08-01
Series:Protein & Cell
Subjects:
NEDDylation
ubiquitination
PCNA
oxidative stress
DNA damage response
Online Access:http://link.springer.com/article/10.1007/s13238-017-0455-x

Internet

http://link.springer.com/article/10.1007/s13238-017-0455-x

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