Blood-Brain Barrier Cellular Responses Toward Organophosphates: Natural Compensatory Processes and Exogenous Interventions to Rescue Barrier Properties

Blood-Brain Barrier Cellular Responses Toward Organophosphates: Natural Compensatory Processes and Exogenous Interventions to Rescue Barrier Properties

Organophosphorus compounds (OPs) are highly toxic chemicals widely used as pesticides (e.g., paraoxon (PX)- the active metabolite of the insecticide parathion) and as chemical warfare nerve agents. Blood-brain barrier (BBB) leakage has been shown in rodents exposed to PX, which is an organophosphate...

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Bibliographic Details
Main Authors: Orly Ravid, Shirin Elhaik Goldman, David Macheto, Yael Bresler, Raquel Ines De Oliveira, Sigal Liraz-Zaltsman, Fabien Gosselet, Lucie Dehouck, Michal Schnaider Beeri, Itzik Cooper
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
blood-brain barrier
organophosphates
paraoxon
tight junction
permeability
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00359/full

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https://www.frontiersin.org/article/10.3389/fncel.2018.00359/full

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