High glucose-mediated oxidative stress impairs cell migration.

Deficient wound healing in diabetic patients is very frequent, but the cellular and molecular causes are poorly defined. In this study, we evaluate the hypothesis that high glucose concentrations inhibit cell migration. Using CHO.K1 cells, NIH-3T3 fibroblasts, mouse embryonic fibroblasts and primary...

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Bibliographic Details
Main Authors: Marcelo L Lamers, Maíra E S Almeida, Miguel Vicente-Manzanares, Alan F Horwitz, Marinilce F Santos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3149607?pdf=render