An Myh11 single lysine deletion causes aortic dissection by reducing aortic structural integrity and contractility

An Myh11 single lysine deletion causes aortic dissection by reducing aortic structural integrity and contractility

Abstract Pathogenic variants in myosin heavy chain (Myh11) cause familial thoracic aortic aneurysms and dissections (FTAAD). However, the underlying pathological mechanisms remain unclear because of a lack of animal models. In this study, we established a mouse model with Myh11 K1256del, the pathoge...

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Bibliographic Details
Main Authors: Keita Negishi, Kenichi Aizawa, Takayuki Shindo, Toru Suzuki, Takayuki Sakurai, Yuichiro Saito, Takuya Miyakawa, Masaru Tanokura, Yosky Kataoka, Mitsuyo Maeda, Shota Tomida, Hiroyuki Morita, Norifumi Takeda, Issei Komuro, Kazuomi Kario, Ryozo Nagai, Yasushi Imai
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-12418-8

Internet

https://doi.org/10.1038/s41598-022-12418-8

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