RADAR: differential analysis of MeRIP-seq data with a random effect model

RADAR: differential analysis of MeRIP-seq data with a random effect model

Abstract Epitranscriptome profiling using MeRIP-seq is a powerful technique for in vivo functional studies of reversible RNA modifications. We develop RADAR, a comprehensive analytical tool for detecting differentially methylated loci in MeRIP-seq data. RADAR enables accurate identification of alter...

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Bibliographic Details
Main Authors: Zijie Zhang, Qi Zhan, Mark Eckert, Allen Zhu, Agnieszka Chryplewicz, Dario F. De Jesus, Decheng Ren, Rohit N. Kulkarni, Ernst Lengyel, Chuan He, Mengjie Chen
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Genome Biology
Subjects:
N 6-adenosine methylation (m6A)
Differential methylation
MeRIP-seq
Online Access:https://doi.org/10.1186/s13059-019-1915-9

Internet

https://doi.org/10.1186/s13059-019-1915-9

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