An early, reversible cholesterolgenic etiology of diet-induced insulin resistance

An early, reversible cholesterolgenic etiology of diet-induced insulin resistance

Objective: A buildup of skeletal muscle plasma membrane (PM) cholesterol content in mice occurs within 1 week of a Western-style high-fat diet and causes insulin resistance. The mechanism driving this cholesterol accumulation and insulin resistance is not known. Promising cell data implicate that th...

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Bibliographic Details
Main Authors: Jacob D. Covert, Brian A. Grice, Matthew G. Thornburg, Manpreet Kaur, Andrew P. Ryan, Lixuan Tackett, Theja Bhamidipati, Natalie D. Stull, Teayoun Kim, Kirk M. Habegger, Donald A. McClain, Joseph T. Brozinick, Jeffrey S. Elmendorf
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Metabolism
Subjects:
Cholesterol
Insulin resistance
Membrane
Skeletal muscle
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877823000492

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http://www.sciencedirect.com/science/article/pii/S2212877823000492

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