MS-Based Allotype-Specific Analysis of Polyclonal IgG-Fc N-Glycosylation

MS-Based Allotype-Specific Analysis of Polyclonal IgG-Fc N-Glycosylation

Current approaches to study glycosylation of polyclonal human immunoglobulins G (IgG) usually imply protein digestion or glycan release. While these approaches allow in-depth characterization, they also result in a loss of valuable information regarding certain subclasses, allotypes and co-occuring...

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Bibliographic Details
Main Authors: Thomas Sénard, Andrea F. G. Gargano, David Falck, Steven W. de Taeye, Theo Rispens, Gestur Vidarsson, Manfred Wuhrer, Govert W. Somsen, Elena Domínguez-Vega
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
immunoglobulin G
allotypes
fragment crystallizable
N-glycosylation
post-translational modifications
mass spectrometry
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02049/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.02049/full

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