New insights in the mechanisms of opioid analgesia and tolerance: Ultramicronized palmitoylethanolamide down-modulates vascular endothelial growth factor-A in the nervous system

New insights in the mechanisms of opioid analgesia and tolerance: Ultramicronized palmitoylethanolamide down-modulates vascular endothelial growth factor-A in the nervous system

Growing evidence suggests that opioid analgesics modulate angiogenesis during pathophysiological processes. Vascular endothelial growth factor-A (VEGF-A) was recently proposed to be involved in pain development. To date, no anti-angiogenic drug is used for pain management. When administered in a bio...

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Bibliographic Details
Main Authors: Laura Micheli, Stefania Nobili, Elena Lucarini, Alessandra Toti, Francesco Margiotta, Clara Ciampi, Daniel Venturi, Lorenzo Di Cesare Mannelli, Carla Ghelardini
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Pharmacological Research
Subjects:
Pain
Opioid
Angiogenesis
Ultramicronized N-palmitoylethanolamine
Nervous system
Bevacizumab
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824004171

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http://www.sciencedirect.com/science/article/pii/S1043661824004171

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