Modulation of tumor immune microenvironment by TAS-115, a multi-receptor tyrosine kinase inhibitor, promotes antitumor immunity and contributes anti-PD-1 antibody therapy

Modulation of tumor immune microenvironment by TAS-115, a multi-receptor tyrosine kinase inhibitor, promotes antitumor immunity and contributes anti-PD-1 antibody therapy

Abstract TAS-115 is an oral multi-receptor tyrosine kinase inhibitor that strongly inhibits kinases implicated in antitumor immunity, such as colony stimulating factor 1 receptor and vascular endothelial growth factor receptor. Because these kinases are associated with the modulation of immune pathw...

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Bibliographic Details
Main Authors: Toshihiro Shibutani, Risa Goto, Isao Miyazaki, Akihiro Hashimoto, Takamasa Suzuki, Keiji Ishida, Tomonori Haruma, Toshihiro Osada, Takafumi Harada, Hidenori Fujita, Shuichi Ohkubo
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-35985-w

Internet

https://doi.org/10.1038/s41598-023-35985-w

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