Molecular iodine-promoted oxidative cyclization for the synthesis of 1,3,4-thiadiazole-fused- [1,2,4]-thiadiazole incorporating 1,4-benzodioxine moiety as potent inhibitors of α-amylase and α-glucosidase: In vitro and in silico study

Molecular iodine-promoted oxidative cyclization for the synthesis of 1,3,4-thiadiazole-fused- [1,2,4]-thiadiazole incorporating 1,4-benzodioxine moiety as potent inhibitors of α-amylase and α-glucosidase: In vitro and in silico study

Twenty-five analogs were synthesized based on 1,3,4-thiadiazole-fused-[1,2,4]-thiadiazole incorporating 1,4-benzodioxine moiety (1–25) and then tested for the antidiabetic profile. The entire afforded derivatives showed varied inhibition profiles ranging between 0.70 ± 0.01 and 30.80 ± 0.80 μM (agai...

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Main Authors: Rafaqat Hussain, Mazloom Shah, Shahid Iqbal, Wajid Rehman, Shoaib Khan, Liaqat Rasheed, Haseena Naz, Hanan A. Al-ghulikah, Eslam B. Elkaeed, Rami Adel Pashameah, Eman Alzahrani, Abd-ElAziem Farouk
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Chemistry
Subjects:
synthesis
4-benzodioxin
thiadiazole-fused-[1,4]-thiadiazole
α-amylase
α-glucosidase
molecular docking
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.1023316/full

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https://www.frontiersin.org/articles/10.3389/fchem.2022.1023316/full

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